Publications

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  1. Sitarik, I., Vu, Q. V., Petucci, J., Frutos, P., Song, H., & O’Brien, E. P. (2025). A widespread protein misfolding mechanism is differentially rescued in vitro by chaperones based on gene essentiality. Nature Communications, 16(1), 10870. Read more

  2. Vu, Q. V., Sitarik, I., Jiang, Y., Xia, Y., Sharma, P., Yadav, D., Song, H., Li, M. S., Fried, S. D., & O’Brien, E. P. (2025). Non-native entanglement protein misfolding observed in all-atom simulations and supported by experimental structural ensembles. Science Advances, 11(32). Read more

  3. Vu, Q. V., Sitarik, I., Li, M. S., & O’Brien, E. P (2025). Noncovalent Lasso Entanglements are Common in Experimentally Derived Intrinsically Disordered Protein Ensembles and Strongly Influenced by Protein Length and Charge. The Journal of Physical Chemistry B. Read more-ACS Editors’ Choice

  4. Lan, P. D., Nissley, D. A., Sitarik, I., Vu, Q. V., Jiang, Y., To, P., Xia, Y., Fried, S. D., Li, M. S., & O’Brien, E. P. (2024) Synonymous Mutations Can Alter Protein Dimerization Through Localized Interface Misfolding Involving Self-entanglements. Journal of Molecular Biology, 436(6), 168487. Read more

  5. Halder, R.; Nissley, D. A.; Sitarik, I.; Jiang, Y.; Rao, Y.; Vu, Q. V; Li, M. S.; Pritchard, J.; O’Brien, E. P (2023). How Soluble Misfolded Proteins Bypass Chaperones at the Molecular Level. Nature Communications, 14 (1), 3689. Read more

  6. Vu, Q. V; Nissley, D. A.; Jiang, Y.; O’Brien, E. P.; Li, M. S (2023). Is Posttranslational Folding More Efficient Than Refolding from a Denatured State: A Computational Study. J. Phys. Chem. B, 127 (21), 4761–4774. Read more

  7. Leininger, S. E.; Rodriguez, J.; Vu, Q. V.; Jiang, Y.; Li, M. S.; Deutsch, C.; O’Brien, E. P (2021). Ribosome Elongation Kinetics of Consecutively Charged Residues Are Coupled to Electrostatic Force. Biochemistry, 60, 43, 3223–3235. Read more

  8. Vu, Q. V.; Jiang, Y.; Li, M. S.; O’Brien, E. P (2021). The Driving Force for Co-translational Protein Folding is Weaker In the Ribosome Vestibule due to Greater Water Ordering. Chemical Science . 12, 11851-11857. Read more

  9. Nissley, D. A.; Vu, Q. V.; Trovato, F.; Ahmed, N.; Jiang, Y.; Li, M. S.; O’Brien, E. P (2020). Electrostatic Interactions Govern Extreme Nascent Protein Ejection Times from Ribosomes and Can Delay Ribosome Recycling. J. Am. Chem. Soc. 142, 13, 6103-6110 . Read more