CV

Postdoctoral Scholar

Department of Chemistry, Penn State University

Investigate molecular mechanisms of protein folding, misfolding, and non-covalent lasso entanglement using atomistic and coarse-grained molecular simulations.

• Computational biophysics
• Molecular dynamics simulations
• Protein folding and misfolding
• Protein topology and entanglement

Physicist

Institute of Physics, Polish Academy of Sciences, Warsaw, Poland

Developed and applied coarse-grained and all-atom simulation models to study co-translational protein folding on the ribosome.

• Coarse-grained simulations
• All-atom simulations
• Co-translational protein folding
• Ribosome-nascent chain interactions

Reviewer

• Communications Chemistry
• Communications Physics
• Nature Communications
• Journal of the American Chemical Society
• Journal of Physical Chemistry B

Doctor of Philosophy

Institute of Physics, Polish Academy of Sciences, Warsaw, Poland

Theoretical Physics, Computational Biophysics

• Computational biophysics
• Molecular dynamics simulations
• Protein folding
• Protein misfolding

Master of Science

Hanoi University of Science, Vietnam National University

Physics

Bachelor of Science

Hanoi University of Science, Vietnam National University

Physics

The Annual Director's Awards for Best PhD Thesis 2023

Institute of Physics, Polish Academy of Sciences, Warsaw, Poland

The Annual Director's Awards for Best PhD Thesis 2023

Creative Youth

Vietnam Association of Science and Technology in Poland

Award for Young Vietnamese Scientist in Poland

Student - Scientific Researching

Hanoi University of Science, Vietnam National University

Student - Scientific Researching. Second prize

PetroVietnam Scholarship

Hanoi University of Science, Vietnam National University

Scholarship for outstanding students

Protein entanglement, misfolding, and aging

Investigate whether native non-covalent lasso entanglements create structural liabilities that promote misfolding and contribute to age-associated proteome remodeling in yeast.

• Entanglement-mediated misfolding
• Age-associated structural change
• Non-covalent lasso entanglement

Molecular mechanisms of entanglement-mediated protein misfolding and disease

Use molecular simulations to characterize how native topological entanglements alter folding pathways, stabilize misfolded states, and shape disease-relevant protein behavior.

• Entanglement-mediated misfolding
• Disease-associated proteins
• Non-covalent lasso entanglement
• Co-translational protein folding

Hydrophobic effect in the ribosome vestibule

Quantified how water ordering in the ribosome vestibule weakens hydrophobic driving forces that can influence nascent-chain folding.

• Hydrophobic effect
• Ribosome vestibule
• Co-translational protein folding
• Water structure

Electrostatic interactions govern extreme nascent protein ejection times from ribosomes and can delay ribosome recycling in E. coli

Studied how electrostatic interactions modulate nascent-protein ejection from the ribosome and can delay ribosome recycling in E. coli.

• Electrostatic interactions
• Nascent-protein ejection
• Ribosome recycling

Protein folding on the ribosome Oral

Event: Theoretical Physics Seminar at Institute of Physics, Polish Academy of Sciences

The driving force for co-translational protein folding is weaker in the ribosome vestibule due to greater water ordering Special oral

Event: The sixth Workshop of Vietnamese Students in Poland

A new class of protein misfolding revealed by all-atom simulations and supported by experiments Poster

Event: 55th Midwest Theoretical Chemistry Conference (MWTCC55)

Native non-covalent lasso entanglement promotes misfolding and contributes to age-related structural change in the Saccharomyces cerevisiae proteome Oral

Event: Gordon Research Conference on Protein Folding Dynamics

Oral presentation on entanglement-mediated misfolding and age-associated structural change in the Saccharomyces cerevisiae proteome.

Native non-covalent lasso entanglement promotes misfolding and contributes to age-related structural change in the Saccharomyces cerevisiae proteome Poster

Event: Gordon Research Conference on Protein Folding Dynamics

Poster presentation on entanglement-mediated misfolding and age-associated structural change in the Saccharomyces cerevisiae proteome.